Post-Translational Modifications

Axoiya is deeply rooted in the development of technologies for identifying and quantitating post-translational modifications (PTMs) of proteins in a reliable and reproducible way. Axoiya technologies streamline sample processing under physiological conditions that enable broad and highly sensitive detection of PTMs to help better understand human biology and assist in discovery and development of next generation therapeutics. 

Protein post translational modifications can significantly affect protein function, influence cellular processes, but also contribute to disease. Despite their importance, PTMs are understudied due to the lack of optimized tools and methods to identify and quantify the entirety of each specific PTM. Axoiya has developed next generation PTM binders that address these problematic areas of recovery and reproducibility. Through the generation of robust protein-based binders optimized for each PTM, Axoiya Sure Capture binders, provide easy to use, automatable processes to be deployed at scale for the sole goal of determining the quantitative landscape of each PTM maximizing the information output of the experiment.

Phosphorylation: 

Phospho-Tyrosine is essential for understanding signal transduction, kinase drug development and stem cell differentiation. 

Phospho-Threonine is essential for understanding cell cycle regulation, stress response and apoptosis research. 

Phospho-Serine is essential for understanding kinase pathway discovery, protein interactions and epigenetics.